| Hypercellular/heterotopic ganglia in omphalomesenteric duct remnants. | |
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MedLine Citation:
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PMID: 11370262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omphalomesenteric duct remnants (ODR) including Meckel diverticula often present with symptoms of bowel obstruction. Their histologic features are varied and include heterotopic gastrointestinal mucosa and/or pancreatic tissue within the wall. Abnormalities of the submucosal plexus of Meissner, however, have not been documented in the literature. Thus, we have examined a number of ODR for evidence of ganglion abnormalities. Fifty-three cases of ODR were retrieved from our archives, along with 25 nonduodenal small bowel control specimens obtained from autopsies of patients without clinical or pathologic evidence of enteropathy. Histologic criteria for the diagnosis of abnormal hypercellular/heterotopic ganglia (HHG) in ODR were defined as a single submucosal ganglion/plexus containing > 10 neurons, or > 5 submucosal ganglions per high-power (x 40) field, or heterotopic ganglion cells within the muscularis mucosa or the lamina propria. HHG, histologically indistinguishable from intestinal neuronal dysplasia type B, were found in more than half of the ODR (ODR: 51.9%, n = 50 vs. control: 4%, n = 25, P = 3.6 x 10(-6), particularly those excised for obstructive complications (ODR with acute abdomen: 65.7%, n = 35, vs. ODR without acute abdomen: 33.3%, n = 15, P = 0.035). HHG were present in equal numbers of inflamed and noninflamed ODR (inflamed: 53.6%, n = 28, vs. noninflamed: 59.1%, n = 22, P = 0.70). A similar incidence was found in ODR with heterotopia and without (with heterotopia: 61.1%, n = 18, vs. without: 53.1%, n = 32, P = 0.59). ODR frequently contained HHG histomorphologically similar to those found in intestinal neuronal dysplasia, type B (IND-B). The overrepresentation of HHG in symptomatic ODR patients suggests an association with bowel obstruction. The data did not demonstrate a relationship with either inflammation or heterotopia. |
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Authors:
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S S Wu; M H Collins; S Coventry; J P de Chadarevian |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 4 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2001 May-Jun |
Date Detail:
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Created Date: 2001-05-23 Completed Date: 2001-09-27 Revised Date: 2006-05-08 |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, MCP Hahnemann University and St. Christopher's Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen, Acute
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etiology,
pathology,
surgery Adolescent Child Child, Preschool Female Humans Infant Infant, Newborn Intestinal Obstruction / etiology, pathology, surgery Male Meckel Diverticulum / pathology*, surgery Retrospective Studies Submucous Plexus / pathology* Vitelline Duct / pathology*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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