| The gang of four gene regulates growth and patterning of the developing Drosophila eye. | |
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MedLine Citation:
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PMID: 20473027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report here the identification of a novel complementation group in the fruit fly Drosophila melanogaster named gang of four (gfr). Mutations in gfr disrupt patterns of cell differentiation in the eye and increase eye size through a proliferative mechanism that can be enhanced by a block in apoptosis. gfr mutant cells show several features of deregulated Ras/MAP kinase activity, including reduced expression of the Capicua growth suppressing transcription factor and synthetically lethality with alleles of the Jun N-terminal kinase phosphatase puckered. gfr alleles also upreguate Notch activity in the eye. Thus, gfr alleles appear to elicit growth and patterning phenotypes via effects on multiple signaling pathways. Moreover, the gfr alleles behave as gain-of-function lesions and overexpress the gene, bruno-3 (bru-3), which is located at the genomic region to which gfr lesions map. Genetic reduction of bru-3 suppresses phenotypes caused by gfr alleles, and like gfr alleles, overexpression of bru-3 depresses levels of Cic protein, indicating that overexpression of bru-3 is central to gfr mutant phenotypes. |
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Authors:
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Carolyn K Beam; Kenneth Moberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-24 |
Journal Detail:
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Title: Fly Volume: 4 ISSN: 1933-6942 ISO Abbreviation: Fly (Austin) Publication Date: 2010 Apr-Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-09-30 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101470897 Medline TA: Fly (Austin) Country: United States |
Other Details:
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Languages: eng Pagination: 104-16 Citation Subset: IM |
Affiliation:
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Emory University School of Medicine, Department of Cell Biology, Atlanta, GA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Animals, Genetically Modified Base Sequence Body Patterning / genetics Cell Death / genetics Chromosome Mapping DNA Primers / genetics Drosophila Proteins / genetics, metabolism Drosophila melanogaster / genetics*, growth & development*, metabolism Eye / growth & development*, metabolism Female Gene Expression Regulation, Developmental Genes, Insect* Genetic Complementation Test Green Fluorescent Proteins / genetics, metabolism MAP Kinase Signaling System / genetics Male Models, Biological Mutation Phenotype Phosphoprotein Phosphatases / genetics, metabolism Receptors, Notch / genetics, metabolism Wing / growth & development, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM079242/GM/NIGMS NIH HHS; R01 CA123368-01/CA/NCI NIH HHS; R01 CA123368-02/CA/NCI NIH HHS; R01 CA123368-03/CA/NCI NIH HHS; R01 CA123368-04/CA/NCI NIH HHS; R01 CA123368-05/CA/NCI NIH HHS; R01 GM079242-01/GM/NIGMS NIH HHS; R01 GM079242-02/GM/NIGMS NIH HHS; R01 GM079242-03/GM/NIGMS NIH HHS; R01 GM079242-04/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Drosophila Proteins; 0/Receptors, Notch; 0/notch protein, Drosophila; 147336-22-9/Green Fluorescent Proteins; EC 3.1.3.-/puc protein, Drosophila; EC 3.1.3.16/Phosphoprotein Phosphatases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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