| Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. | |
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MedLine Citation:
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PMID: 21555560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. Here we show that γδ intraepithelial lymphocytes (γδ IEL) of the small intestine produce innate antimicrobial factors in response to resident bacterial "pathobionts" that penetrate the intestinal epithelium. γδ IEL activation was dependent on epithelial cell-intrinsic MyD88, suggesting that epithelial cells supply microbe-dependent cues to γδ IEL. Finally, γδ T cells protect against invasion of intestinal tissues by resident bacteria specifically during the first few hours after bacterial encounter, indicating that γδ IEL occupy a unique temporal niche among intestinal immune defenses. Thus, γδ IEL detect the presence of invading bacteria through cross-talk with neighboring epithelial cells and are an essential component of the hierarchy of immune defenses that maintain homeostasis with the intestinal microbiota. |
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Authors:
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Anisa S Ismail; Kari M Severson; Shipra Vaishnava; Cassie L Behrendt; Xiaofei Yu; Jamaal L Benjamin; Kelly A Ruhn; Baidong Hou; Anthony L DeFranco; Felix Yarovinsky; Lora V Hooper |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-09 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-25 Completed Date: 2011-10-07 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8743-8 Citation Subset: IM |
Affiliation:
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Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GEO/GSE28437 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / immunology Cell Communication / immunology Epithelial Cells Homeostasis / immunology* Host-Pathogen Interactions / immunology* Immunity, Innate Intestinal Mucosa / immunology* Lymphocytes / immunology* Metagenome / immunology Mice Mice, Knockout Receptors, Antigen, T-Cell, gamma-delta / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI078869/AI/NIAID NIH HHS; R01 AI072058-05/AI/NIAID NIH HHS; R01 DK070855/DK/NIDDK NIH HHS; R01 DK070855-06/DK/NIDDK NIH HHS; T32 AI005284/AI/NIAID NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, T-Cell, gamma-delta |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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