| gammaH2AX as a checkpoint maintenance signal. | |
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MedLine Citation:
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PMID: 16855385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A key function of the conserved signaling cascade triggered by DNA damage is to promote the arrest or pause of cell cycle progression, a phenomenon commonly termed a "checkpoint". This response allows time for DNA repair to proceed before entering a new phase of the cell cycle. Although much is known about the initiation and propagation of this signaling pathway, much less is understood about the mechanisms that lead to its extinction. Recent work highlights a role for H2AX phosphorylation as a checkpoint maintenance factor and of its dephosphorylation as a signal for resumption of the cell cycle. |
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Authors:
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Michael Downey; Daniel Durocher |
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Publication Detail:
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Type: Journal Article Date: 2006-07-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-24 Completed Date: 2006-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1376-81 Citation Subset: IM |
Affiliation:
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Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Chromatin / genetics DNA / genetics DNA Repair Histones / genetics, metabolism* Humans Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Histones; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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