| gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. | |
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MedLine Citation:
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PMID: 18602811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tocotrienols are naturally occurring isoprenoid compounds highly enriched in palm oil, rice bran, oat, wheat germ, barley and rye. Tocotrienols have antioxidant properties as well as potent anticancer properties. In this study, the mechanisms underlying the apoptosis of gamma-tocotrienol on human gastric adenocarcinoma SGC-7901 cells were further studied, especially in correlation with the involvement of the apoptotic pathway. gamma-Tocotrienol inhibited SGC-7901 cell growth in a concentration- and time-dependent manner. The inhibitory effects of SGC-7901 cells were correlated with the DNA damage and arresting cell cycle at G(0)/G(1) phase in a time-dependent manner at 60 mumol/L concentration of gamma-tocotrienol. gamma-Tocotrienol induced activation of caspase-3 and increased the cleavage of the downstream substrate poly(ADP-ribose) polymerase. Furthermore, gamma-tocotrienol-induced apoptosis on SGC-7901 cells was mediated by activation of caspase-9. The data in this study suggested that gamma-tocotrienol could induce the apoptosis on human gastric cancer SGC-7901 cells via mitochondria-dependent apoptosis pathway. Thus, our findings revealed gamma-tocotrienol as a potential, new chemopreventive agent for human gastric cancer. |
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Authors:
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Wenguang Sun; Weili Xu; Huikun Liu; Jiaren Liu; Qi Wang; Jin Zhou; Fengli Dong; Bingqing Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-07 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 20 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-16 Completed Date: 2009-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 276-84 Citation Subset: IM |
Affiliation:
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Department of Clinic Nutrition, the First Clinical College of Harbin Medical University, Nangang District, Harbin 150001, P.R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism* Anticarcinogenic Agents / pharmacology* Antioxidants / pharmacology Apoptosis* Caspase 3 / metabolism Caspase 9 / metabolism Cell Cycle Cell Line, Tumor Chromans / pharmacology* DNA Damage Humans Mitochondria / metabolism* Poly(ADP-ribose) Polymerases / metabolism Stomach Neoplasms / metabolism* Vitamin E / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Antioxidants; 0/Chromans; 1406-18-4/Vitamin E; 4382-43-8/plastochromanol 8; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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