Document Detail

gamma-Hexachlorocyclohexane stimulation of macrophage phospholipid hydrolysis and leukotriene production.
MedLine Citation:
PMID:  6200116     Owner:  NLM     Status:  MEDLINE    
gamma-Hexachlorocyclohexane stimulates arachidonic acid release from macrophage phospholipids. It is also a powerful stimulator of leukotriene C4 production, yet (by comparison with zymosan) produces only a small effect on prostaglandin production. This suggests that synthesis of leukotrienes and prostaglandins can be independently regulated. The most likely mechanism of action of gamma-hexachlorocyclohexane is through its effect on phosphatidylinositol metabolism.
C J Meade; J Harvey; J R Boot; G A Turner; P E Bateman; D J Osborne
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  33     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-04-04     Completed Date:  1984-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Lindane / pharmacology*
Macrophages / drug effects,  metabolism*
Phospholipids / metabolism*
SRS-A / biosynthesis*
Reg. No./Substance:
0/Arachidonic Acids; 0/Phospholipids; 0/SRS-A; 506-32-1/Arachidonic Acid; 58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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