Document Detail

gamma-Glutamylamine cyclotransferase. An enzyme involved in the catabolism of epsilon-(gamma-glutamyl)lysine and other gamma-glutamylamines.
MedLine Citation:
PMID:  6117008     Owner:  NLM     Status:  MEDLINE    
gamma-Glutamylamine cyclotransferase, an enzyme found in a number of animal tissues and cells, catalyzes the conversion of epsilon-(L-gamma-glutamyl)-L-lysine to free lysine and 5-oxo-L-proline as well as the release of free amines and the formation of 5-oxo-L-proline from a variety of other L-gamma-glutamylamines. Among its substrates are both the mon- and di-gamma-glutamyl derivatives of putrescine, spermidine and spermine, and a derivative of epsilon-(L-gamma-glutamyl)-L-lysine in which both the alpha-amino group and the carboxyl group of the lysine moiety are blocked. The enzyme does not act on most gamma-glutamyl-alpha-amino acids, nor is it active toward the epsilon-lysyl derivatives of L-aspartic acid or D-glutamic acid. Derivatives of epsilon-(L-gamma-glutamyl)-L-lysine in which the alpha-amino or the alpha-carboxyl function of the glutamyl moiety is blocked also do not serve as substrates. The specificity of gamma-glutamylamine cyclotransferase is in accordance with the proposal that it functions biologically in the latter stages of the catabolism of products of the action of transglutaminases. Some suggestions as to the manner in which gamma-glutamylamine cyclotransferase serves this function are made based on present knowledge of protein degradation.
M L Fink; J E Folk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  38 Spec No     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-67     Citation Subset:  IM    
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MeSH Terms
Acyltransferases / metabolism*
Dipeptides / metabolism*
Kidney / enzymology
Substrate Specificity
gamma-Glutamylcyclotransferase / metabolism*
gamma-Glutamyltransferase / metabolism
Reg. No./Substance:
0/Dipeptides; 17105-15-6/epsilon-(gamma-glutamyl)-lysine; EC 2.3.-/Acyltransferases; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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