| gamma-Aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis. | |
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MedLine Citation:
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PMID: 4088534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular levels of striatal gamma-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids. |
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Authors:
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U Tossman; T Wieloch; U Ungerstedt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 62 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-03-26 Completed Date: 1986-03-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 231-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Striatum / analysis, metabolism*, physiopathology Dialysis Electroencephalography Hypoglycemia / metabolism* Insulin Coma / metabolism*, physiopathology Male Microinjections Neurons / metabolism, physiology Rats Rats, Inbred Strains Taurine / metabolism* Time Factors gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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5 N01 NS07838/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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107-35-7/Taurine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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