| gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. | |
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MedLine Citation:
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PMID: 8058598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice. Muscimol, AOAA, DABA, phenobarbitone and diazepam significantly protected mice against pentylenetetrazol-induced seizures and also significantly potentiated the protective effect of clonidine against the seizures. Bicuculline and picrotoxin significantly potentiated seizures induced by pentylenetetrazol and significantly attenuated both the protective effects of muscimol and clonidine against the seizures. These data suggest that activation of gamma-aminobutyric acid systems may underlie the protective effect of clonidine against seizures induced by pentylenetetrazol in mice. |
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Authors:
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G Amabeoku; O Chikuni; E Bwakura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 29 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-09-12 Completed Date: 1994-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 273-80 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Medical School, University of Zimbabwe, Avondale, Harare. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clonidine / therapeutic use* Disease Models, Animal Mice Pentylenetetrazole Seizures / drug therapy*, prevention & control gamma-Aminobutyric Acid / administration & dosage |
| Chemical | |
Reg. No./Substance:
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4205-90-7/Clonidine; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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