Document Detail


Is galectin-3 antibody a useful marker in the diagnosis of malignant pleural mesothelioma?
MedLine Citation:
PMID:  23537297     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Malignant pleural mesothelioma (MPM) is a challenging diagnosis characterized by the absence of real specific diagnostic markers. Positivity with the galectin-3 antibody was assessed by a cytoplasmic expression in 17 MPM. Fourteen cases expressed the galectin-3 antibody. The three negative cases consisted of epithelioid, biphasic, and sarcomatoid MPM. The 14 positive cases consisted of epithelioid MPM in 12 cases, sarcomatoid MPM in one case, and biphasic MPM in one case. In spite of our inability to prove the real diagnostic value of the galectin-3 antibody, our findings make us wonder about the implication of this antibody in the carcinogenesis of MPM.
Authors:
Mona Mlika; Aida Ayadi-Kaddour; Meriem Ksantini; Saadia Bouraoui; Sabah Mzabi; Faouzi El Mezni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of immunoassay & immunochemistry     Volume:  34     ISSN:  1532-4230     ISO Abbreviation:  J Immunoassay Immunochem     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963688     Medline TA:  J Immunoassay Immunochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-25     Citation Subset:  IM    
Affiliation:
a Department of Pathology , Abderrahman Mami Hospital , Ariana , Tunis , Tunisia.
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