| The galanin antagonist, M-15, inhibits growth hormone release in rats. | |
| | |
MedLine Citation:
|
PMID: 7687353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The neuropeptide, galanin, has been implicated in the regulation of rat growth hormone (rGH) release. In the present study, adult male rats were implanted dually with cannulae to the lateral cerebral ventricle and the right atrium. After surgical recovery, rats were infused with M-15, a specific galanin antagonist, into the lateral ventricle. During the course of this brain infusion, rats were subjected to serial blood sampling with red cell and artificial plasma replacement under stress-free conditions. Plasma was saved for rGH assay. Treatment with M-15 reduced rGH pulse amplitude and pulse frequency when compared to vehicle-infused controls. These data suggest that brain galanin participates in the ongoing stimulation of pulsatile rGH release in the adult male rat. |
| | |
Authors:
|
S M Gabriel; A Rivkin; J Mercado |
Related Documents
:
|
1850633 - A 7-34 analog of the parathyroid hormone-related protein has potent antagonist and part... 96203 - Pyroglutamyl-n3im-methyl-histidyl-prolineamide (methyl-thyrotrophin releasing hormone) ... 9630843 - Involvement of cyp3a1, 2b1, and 2e1 in c-8 hydroxylation and cyp 1a2 and flavin-contain... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Peptides Volume: 14 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1993 May-Jun |
Date Detail:
|
Created Date: 1993-08-16 Completed Date: 1993-08-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 633-6 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10024. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Galanin Growth Hormone / secretion* Male Neuropeptides / antagonists & inhibitors* Peptide Fragments / pharmacology* Peptides / antagonists & inhibitors*, pharmacology* Rats Rats, Sprague-Dawley Secretory Rate / drug effects Substance P / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
MH-45480/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neuropeptides; 0/Peptide Fragments; 0/Peptides; 138579-66-5/galantide; 33507-63-0/Substance P; 88813-36-9/Galanin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation, identification, and synthesis of PDVDHFLRFamide (SchistoFLRFamide) in Locusta migratoria ...
Next Document: C-erbB-2 oncogene product expression depends on tumour type and is related to oestrogen receptor and...