Document Detail

The future of stroke thrombolysis.
MedLine Citation:
PMID:  22994215     Owner:  NLM     Status:  In-Data-Review    
Studies with tissue plasminogen activator (t-PA) published in 1995 showed significant improvement in stroke outcome if the drug was administered within 3 hours from stroke onset. Several recent reports, however, show that less than 5% of stroke patients may be receiving t-PA in many parts of North America. This paper explores how this may be improved by examining some of the steps taken in Canada, where a recent audit showed that 8.2% of ischemic stroke patients received t-PA, and in those arriving within 2.5 hours to regional stroke centers in Ontario, 42.2% received t-PA. The paper also reviews the potential for t-PA to be given by more physicians, in remote regions using Telestroke, the possibility for using imaging characteristics rather than the onset of stroke as a determinant of eligibility for t-PA, the status of contraindications for thrombolysis, and the possibility of combining t-PA with immune modulation for improved stroke outcomes.
Antoine M Hakim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1268     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
Copyright Information:
© 2012 New York Academy of Sciences.
University of Ottawa Brain and Mind Research Institute, Ottawa Hospital Research Institute, Canadian Stroke Network, The Heart and Stroke Foundation Center for Stroke Recovery, Division of Neurology, University of Ottawa, Ottawa, Ontario, Canada.
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