Document Detail


The future role of defibrillators in the management of atrial fibrillation.
MedLine Citation:
PMID:  9132075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Episodes of sustained atrial fibrillation have long been effectively treated with external, transthoracic defibrillation. Despite concomitant, postcardioversion therapy with antiarrhythmic agents, patients will frequently have additional episodes of atrial fibrillation requiring either repeat external cardioversion or treatment with either pharmacologic or additional nonpharmacologic therapies. The limited long-term efficacy of different treatment regimens has resulted in the development and evaluation of newer, nonpharmacologic therapeutic options including the implantable atrial defibrillator. The feasibility of an implantable atrial defibrillator has been supported by recent advances in the areas of implantable ventricular defibrillators, including device size and transvenous lead systems. The concept is also supported by the demonstration in recent studies that transvenous, internal cardioversion of atrial fibrillation is possible using low energy shocks. Preliminary data suggest that low-energy atrial defibrillation shocks synchronized to an R wave with a relatively long coupling interval does not result in potentially lethal ventricular arrhythmias. Patient tolerance, and therefore acceptance of therapy, is presently a topic of significant concern and evaluation. Although present data suggest that the concept of an implantable atrial defibrillator is a potential treatment option for recurrent, persistent atrial fibrillation, significant clinical evaluation is required to define the patient population and overall clinical use of this type of device, either as a stand-alone therapy or in combination with other pharmacologic and nonpharmacologic therapies.
Authors:
G M Ayers; J C Griffin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cardiology     Volume:  12     ISSN:  0268-4705     ISO Abbreviation:  Curr. Opin. Cardiol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2006-05-04    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Affiliation:
InControl, Inc., Redmond, WA 98052, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Fibrillation / therapy*
Defibrillators, Implantable*
Equipment Design
Humans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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