Document Detail


The future looks bright: low-cost fluorescent microscopes for detection of Mycobacterium tuberculosis and Coccidiae.
MedLine Citation:
PMID:  18405928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In many resource-poor countries, diagnosis of tuberculosis is based on microscopy of Ziehl-Neelsen-stained smears. However, the fluorescent stain auramine performs better and allows the detection of more positive smears. The limitation for its widespread use has been the high cost for fluorescent microscopes, especially the frequent replacement of the expensive light source, which lasts only 200-300 h. Novel light-emitting diodes (LED) are alternatives and last ten thousands of hours. Based on LEDs, rather inexpensive solutions for fluorescent microscopes are now available and thus auramine may be a cost-effective step to improve the diagnosis of tuberculosis in resource-poor countries.
Authors:
Thomas Hänscheid
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-04-10
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  102     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  520-1     Citation Subset:  IM    
Affiliation:
Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal. t.hanscheid@fm.ul.pt
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzophenoneidum / diagnostic use*
Coccidia / isolation & purification
Coccidiosis / diagnosis*
Coloring Agents / diagnostic use*
Costs and Cost Analysis
Equipment Design
Humans
Microscopy, Fluorescence / methods*,  standards
Mycobacterium tuberculosis / isolation & purification*
Staining and Labeling / methods
Tuberculosis, Pulmonary / diagnosis*
Chemical
Reg. No./Substance:
0/Coloring Agents; 2465-27-2/Benzophenoneidum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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