Document Detail


The future of food allergy therapeutics.
MedLine Citation:
PMID:  22735939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and growth delay as well as psychosocial burdens and the potential for fatal anaphylaxis. There is currently no effective form of therapy, and the mainstay of treatment remains strict avoidance. However, there are a number of promising therapeutic strategies currently being investigated for the treatment of food allergies. Allergen-specific approaches, such as various forms of immunotherapy, have been a major focus of investigation and appear to be promising methods of desensitization. More recently, the addition of anti-IgE monoclonal antibodies (mAbs) to immunotherapy regimens has been studied. Early work with antigen-fixed leukocytes in a murine model has shown promise in inducing tolerance, as have vaccines containing modified recombinant food proteins coadministered with heat-killed Escherichia coli. Nonspecific approaches include a Chinese herbal formulation, anti-IgE mAbs, and Trichuris suis ova therapy. The array of treatment modalities currently being investigated increases the likelihood of finding one or more effective therapies for the treatment of food allergy.
Authors:
Michele Henson; A Wesley Burks
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-06-27
Journal Detail:
Title:  Seminars in immunopathology     Volume:  34     ISSN:  1863-2300     ISO Abbreviation:  Semin Immunopathol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-15     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  703-14     Citation Subset:  IM    
Affiliation:
Duke University Medical Center, Durham, NC, USA. michele.henson@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Animals
Antibodies, Monoclonal / immunology,  therapeutic use*
Desensitization, Immunologic / methods*,  trends*
Disease Models, Animal
Food Hypersensitivity / immunology,  therapy*
Humans
Mice
Grant Support
ID/Acronym/Agency:
T32 AI007062/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies, Monoclonal
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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