| PET/CT fusion scan enhances CT staging in patients with pancreatic neoplasms. | |
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MedLine Citation:
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PMID: 18551347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The role of fusion positron emission tomography/computed tomography scans (PET/CT) in staging of patients with pancreatic neoplasms (PN) is poorly defined. PET/CT may serve as an adjunct to standard imaging by increasing occult metastases detection. The purpose of this study was to assess the additional value, in relation to computed tomography (CT), of PET/CT imaging for patients with PN. METHODS: Eighty-two patients with potentially resectable PN underwent staging with PET/CT and CT of the chest and abdomen. Sensitivity of diagnosing pancreatic cancer by PET/CT avidity was evaluated. The sensitivity of detecting metastases was compared between PET/CT, standard CT, and the combination of PET/CT and CT. The impact of PET/CT on patient management was estimated by calculating the percentage of patients whose treatment plan was altered due to PET/CT. RESULTS: The sensitivity and specificity of PET/CT in diagnosing pancreatic cancer were 89% and 88%, respectively. Sensitivity of detecting metastatic disease for PET/CT alone, standard CT alone, and the combination of PET/CT and CT were 61%, 57%, and 87%, respectively. Findings on PET/CT influenced the clinical management in seven patients (11%), two with a supraclavicular lymph node (LN), two occult liver lesions, two peritoneal implants, and one peri-esophageal LN. CONCLUSION: This study evaluated PET/CT in the initial work-up of patients with PN. PET/CT increased sensitivity (87%) for detection of metastatic disease when combined with standard CT. In invasive cancer, PET/CT changed the management in 11% of our patients. PET/CT should be considered in the initial work-up of patients with potentially resectable pancreatic lesions. |
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Authors:
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Jeffrey M Farma; Alfredo A Santillan; Marcovalerio Melis; Janet Walters; Daly Belinc; Dung-Tsa Chen; Edward A Eikman; Mokenge Malafa |
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Publication Detail:
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Type: Journal Article Date: 2008-06-13 |
Journal Detail:
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Title: Annals of surgical oncology Volume: 15 ISSN: 1534-4681 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 2465-71 Citation Subset: IM |
Affiliation:
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Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis*,
radiography,
radionuclide imaging Adult Aged Aged, 80 and over Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Processing, Computer-Assisted Lymph Nodes / pathology Lymphatic Metastasis Male Middle Aged Neoplasm Recurrence, Local / diagnosis* Neoplasm Staging Pancreatic Neoplasms / diagnosis*, radiography, radionuclide imaging Positron-Emission Tomography / methods* Prospective Studies Radiopharmaceuticals / diagnostic use* Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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