Document Detail

A further study of a possible locus for schizophrenia on the X chromosome.
MedLine Citation:
PMID:  16650384     Owner:  NLM     Status:  MEDLINE    
Several studies suggest that the X chromosome may contain a gene for schizophrenia. In the present study, we recruited 142 male schizophrenic patients and their biological mothers from all parts of the United Kingdom to detect a genetic association for the SYP/CACNA1F locus in the Xp11 region and the FACL4 locus in the Xq22.3-Xq23 region. The haplotype-based haplotype relative risk (HHRR) analysis showed allelic association for rs2071316 (chi2=6.85, P=0.009) and rs5905724 (chi2=5.3, P=0.021) at the CACNA1F locus, but not for rs5943414 and rs1324805 at the FACL4 locus and rs3817678 at the SYP locus. The haplotype analysis showed a weak association for the rs3817678-rs2071316-rs5905724 haplotypes (chi2=12.19, df=4, P=0.016) but did not show such an association for the rs5943414-rs1324805 haplotypes (chi2=3.96, df=2, P=0.138). Because the linkage disequilibrium signal was detected only at the CACNA1F locus, this gene should perhaps be considered as being a candidate for schizophrenia although further work is needed to draw firm conclusions.
Jun Wei; Gwynneth P Hemmings
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Publication Detail:
Type:  Journal Article     Date:  2006-05-02
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  344     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-09     Completed Date:  2006-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-5     Citation Subset:  IM    
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bangor, Gwynedd LL57 2AG, UK.
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MeSH Terms
Calcium Channels, L-Type / genetics*
Chromosome Mapping
Chromosomes, Human, X / genetics*
Coenzyme A Ligases / genetics
Gene Frequency
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Schizophrenia / genetics*
Reg. No./Substance:
0/CACNA1F protein, human; 0/Calcium Channels, L-Type; EC 6.2.1.-/Coenzyme A Ligases; EC ligase

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