Document Detail


A further study of a possible locus for schizophrenia on the X chromosome.
MedLine Citation:
PMID:  16650384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies suggest that the X chromosome may contain a gene for schizophrenia. In the present study, we recruited 142 male schizophrenic patients and their biological mothers from all parts of the United Kingdom to detect a genetic association for the SYP/CACNA1F locus in the Xp11 region and the FACL4 locus in the Xq22.3-Xq23 region. The haplotype-based haplotype relative risk (HHRR) analysis showed allelic association for rs2071316 (chi2=6.85, P=0.009) and rs5905724 (chi2=5.3, P=0.021) at the CACNA1F locus, but not for rs5943414 and rs1324805 at the FACL4 locus and rs3817678 at the SYP locus. The haplotype analysis showed a weak association for the rs3817678-rs2071316-rs5905724 haplotypes (chi2=12.19, df=4, P=0.016) but did not show such an association for the rs5943414-rs1324805 haplotypes (chi2=3.96, df=2, P=0.138). Because the linkage disequilibrium signal was detected only at the CACNA1F locus, this gene should perhaps be considered as being a candidate for schizophrenia although further work is needed to draw firm conclusions.
Authors:
Jun Wei; Gwynneth P Hemmings
Related Documents :
20819984 - Impaired intellect and memory: a missing link between genetic risk and schizophrenia?
15108174 - Association of the hopa12bp allele with a large x-chromosome haplotype and positive sym...
1621064 - Are we overestimating the genetic contribution to schizophrenia?
1798824 - Codistribution of a sensory gating deficit and schizophrenia in multi-affected families.
24218524 - Autosomal-recessive cerebellar ataxia caused by a novel adck3 mutation that elongates t...
16972194 - Illness representations, self-regulation, and genetic counseling: a theoretical review.
Publication Detail:
Type:  Journal Article     Date:  2006-05-02
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  344     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-09     Completed Date:  2006-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-5     Citation Subset:  IM    
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bangor, Gwynedd LL57 2AG, UK. jwei@litbio.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Calcium Channels, L-Type / genetics*
Chromosome Mapping
Chromosomes, Human, X / genetics*
Coenzyme A Ligases / genetics
Female
Gene Frequency
Haplotypes
Humans
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide
Schizophrenia / genetics*
Chemical
Reg. No./Substance:
0/CACNA1F protein, human; 0/Calcium Channels, L-Type; EC 6.2.1.-/Coenzyme A Ligases; EC 6.2.1.3/long-chain-fatty-acid-CoA ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric ca...
Next Document:  Superoxide radical production by allopurinol and xanthine oxidase.