Document Detail


The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.
MedLine Citation:
PMID:  23032214     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.
Authors:
E Zachary Oblak; Erin S D Bolstad; Sophia N Ononye; Nigel D Priestley; M Kyle Hadden; Dennis L Wright
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA. dennis.wright@uconn.edu.
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