| The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs. | |
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MedLine Citation:
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PMID: 23032214 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells. |
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Authors:
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E Zachary Oblak; Erin S D Bolstad; Sophia N Ononye; Nigel D Priestley; M Kyle Hadden; Dennis L Wright |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-3 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA. dennis.wright@uconn.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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