Document Detail

A fungal gene for antibiotic resistance on a dispensable ("B") chromosome.
MedLine Citation:
PMID:  1763326     Owner:  NLM     Status:  MEDLINE    
A family of cytochrome P-450 (Pda) genes in the pathogenic fungus Nectria haematococca is responsible for the detoxification of the phytoalexin pisatin, an antimicrobial compound produced by garden pea (Pisum sativum L.). The Pda6 gene was mapped by electrophoretic karyotype analysis to a small meiotically unstable chromosome that is dispensable for normal growth. Such traits are typical of B chromosomes. The strains of Nectria studied here have no sequences that are homologous to the Pda family other than Pda6 and therefore demonstrate that unique, functional genes can be found on B chromosomes. Unstable B chromosomes may be one mechanism for generating pathogenic variation in fungi.
V P Miao; S F Covert; H D VanEtten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  254     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-12     Completed Date:  1992-02-12     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1773-6     Citation Subset:  IM    
Department of Plant Pathology, Cornell University, Ithaca, NY 14853.
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MeSH Terms
Benzopyrans / metabolism
Chromosome Mapping
Chromosomes, Fungal*
Crosses, Genetic
Cytochrome P-450 Enzyme System / genetics*
Drug Resistance, Microbial / genetics*
Genes, Fungal*
Hypocreales / genetics*
Plants, Medicinal
Reg. No./Substance:
0/Benzopyrans; 0/Pterocarpans; 20186-22-5/pisatin; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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