Document Detail


A fundamental study on hyper-thermal neutrons for neutron capture therapy.
MedLine Citation:
PMID:  15551549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The utilization of hyper-thermal neutrons, which have an energy spectrum with a Maxwellian distribution at a higher temperature than room temperature (300 K), was studied in order to improve the thermal neutron flux distribution at depth in a living body for neutron capture therapy. Simulation calculations were carried out using a Monte Carlo code 'MCNP-V3' in order to investigate the characteristics of hyper-thermal neutrons, i.e. (i) depth dependence of the neutron energy spectrum, and (ii) depth distribution of the reaction rate in a water phantom for materials with 1/v neutron absorption. It is confirmed that hyper-thermal neutron irradiation can improve the thermal neutron flux distribution in the deeper areas in a living body compared with thermal neutron irradiation. When hyper-thermal neutrons with a 3000 K Maxwellian distribution are incident on a body, the reaction rates of 1/v materials such as 14N, 10B etc are about twice that observed for incident thermal neutrons at 300 K, at a depth of 5 cm. The limit of the treatable depth for tumours having 30 ppm 10B is expected to be about 1.5 cm greater by utilizing hyper-thermal neutrons at 3000 K compared with the incidence of thermal neutrons at 300 K.
Authors:
Y Sakurai; T Kobayashi; K Kanda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physics in medicine and biology     Volume:  39     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  1994 Dec 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2004-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2217-27     Citation Subset:  IM    
Affiliation:
Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka 590-04, Japan.
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology
Gamma Rays
Humans
Models, Theoretical
Monte Carlo Method
Neutron Capture Therapy / instrumentation*,  methods*
Neutrons*
Phantoms, Imaging
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods
Temperature

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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