Document Detail

The functions of two species of calcium channel in cardiac muscle excitation-contraction coupling.
MedLine Citation:
PMID:  9049537     Owner:  NLM     Status:  MEDLINE    
The contractile state of cardiac muscle cell is determined by the level of calcium in the cytosol. Each action potential produces a transient elevation of cytosolic calcium. The interaction of calcium ions with the contractile elements of the cell initiates a series of events which culminate in cell shortening. The process by which cell excitation is coupled to contraction involves the function of two distinct species of calcium-selective membrane ion channel; the L-type, dihydropyridine-sensitive calcium channel of the cell surface membrane or sarcolemma and the ryanodine-sensitive calcium-release channel of the sarcoplasmic reticulum intracellular membrane network. The aim of this article is to provide information on the properties of these channels and to discuss the mechanisms involved in the coordination of their function in the coupling of cardiac muscle cell excitation to contraction.
A J Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European heart journal     Volume:  18 Suppl A     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  A27-35     Citation Subset:  IM    
National Heart and Lung Institute, Imperial College, London, U.K.
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MeSH Terms
Calcium / metabolism
Calcium Channels / drug effects,  physiology*
Calcium Channels, L-Type
Calmodulin-Binding Proteins / physiology*
Heart / drug effects,  physiology*
Muscle Proteins / drug effects,  physiology*
Myocardial Contraction / physiology*
Myocardium / cytology,  metabolism
Ryanodine Receptor Calcium Release Channel
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Calcium Channels; 0/Calcium Channels, L-Type; 0/Calmodulin-Binding Proteins; 0/Muscle Proteins; 0/Ryanodine Receptor Calcium Release Channel; 7440-70-2/Calcium

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