| The functions and regulation of the PTEN tumour suppressor. | |
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MedLine Citation:
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PMID: 22473468 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Consequently, mechanisms regulating PTEN expression and function, including transcriptional regulation, post-transcriptional regulation by non-coding RNAs, post-translational modifications and protein-protein interactions, are all altered in cancer. The repertoire of PTEN functions has recently been expanded to include phosphatase-independent activities and crucial functions within the nucleus. Our increasing knowledge of PTEN and pathologies in which its function is altered will undoubtedly inform the rational design of novel therapies. |
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Authors:
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Min Sup Song; Leonardo Salmena; Pier Paolo Pandolfi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-04 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: - ISSN: 1471-0080 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston Massachuchetts 02215, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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