| On functions of cholinesterases during embryonic development. | |
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MedLine Citation:
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PMID: 17192676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Expression of cholinesterase (ChE) activity during phases of embryonic development is a general phenomenon in embryonic tissues. To elucidate the role(s) of ChEs during embryonic development, one line of research followed the assumption of a primitive muscarinic system involved in morphogenesis (Hohmann et al., 1995). This means that ChE functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ACh), as a signal, binds to ACh receptors and then is degraded by acetylcholinesterase (AChE) as the terminating enzyme. However, this is just one of the possible mechanisms. The other line of research was driven by evidence for noncholinergic functions of ChE proteins (AChE and butyrylcholinesterase [BChE]). There is accumulating data that other sites on AChE could exert nonclassical roles related to cell differentiation, neurite outgrowth, and adhesion. |
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Authors:
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Laura E Paraoanu; Gunnar Steinert; Janine Klaczinski; Michaela Becker-Röck; Afrim Bytyqi; Paul G Layer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of molecular neuroscience : MN Volume: 30 ISSN: 0895-8696 ISO Abbreviation: J. Mol. Neurosci. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-12-28 Completed Date: 2007-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002991 Medline TA: J Mol Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 201-4 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Darmstadt University of Technology, 64287 Darmstadt, Germany. paraoanu@BIO.TU-Darmstadt.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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genetics,
metabolism* Animals Butyrylcholinesterase / genetics, metabolism* Cell Adhesion Molecules / metabolism Cell Differentiation Cell Division Embryonic Development / physiology* Neurites / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; EC 3.1.1.-/Butyrylcholinesterase; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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