Document Detail

The functioning in unanaesthetized sheep of the popliteal lymph node after the surgical removal of its blood supply.
MedLine Citation:
PMID:  3814497     Owner:  NLM     Status:  MEDLINE    
Operations were performed to cannulate the efferent duct of the popliteal node of sheep and, at the same time, the blood vascular system was removed surgically from the popliteal fossa so that the node was deprived of it blood supply. Twelve preparations were technically successful in that lymph flowed spontaneously from the unanaesthetised sheep for from 3 to 30 days after the operation. Eight control preparations were established in which the blood supply of the node with the cannulated efferent duct was left intact. In only four of the test preparations was the function of the node decisively impaired so that dendritic macrophages appeared in the lymph, the output of lymphocytes remained very low, and later histological examination showed the nodes to be grossly depleted of lymphocytes. In two of these four preparations the surgical devascularization of the node was aided by arterial embolization. In the remaining eight test preparations the outputs of lymphocytes in the lymph gradually regained normal values, and the nodes then responded normally to antigenic stimuli.
J G Hall; H D Sinnett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  68     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-04-17     Completed Date:  1987-04-17     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
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MeSH Terms
Cell Count
Lymph / cytology,  immunology
Lymph Nodes / blood supply,  pathology,  physiology*
Sheep / physiology*
Time Factors

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