Document Detail

A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.
MedLine Citation:
PMID:  16142870     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Angiogenesis, the formation of new blood vessels, may play a role in giant cell arteritis (GCA), the most common type of systemic vasculitis in the elderly in Western countries. Vascular endothelial growth factor (VEGF) is one of the most important proangiogenic mediators. We wanted to assess the potential role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants in GCA susceptibility and clinical ischemic complications. METHODS: One hundred and three patients with biopsy-proven GCA and 226 ethnically matched controls from the Lugo region (Northwest Spain) were genotyped for the VEGF -1154 G-->A and -634 G-->C polymorphisms using a real time polymerase chain reaction technology based on TaqMan 5' allelic discrimination assay. RESULTS: No significant differences in allele or genotype frequencies for the 2 VEGF polymorphisms were observed between patients and controls. However, the VEGF -634 G allele was significantly more frequent among GCA patients with severe ischemic complications compared with GCA patients not affected by ischemic events (p = 0.017, odds ratio, OR: 2.05; 95% confidence interval, CI: 1.13-3.71; pc = 0.034) or with controls (p = 0.021, OR: 1.75; 95% CI: 1.08-2.88; pc = 0.042). In this regard, the carriage rate of the risk allele G showed statistically significant skewing comparing GCA patients with severe ischemic events with the remaining GCA patients (GG + GC vs CC: p = 0.009, OR: 5.26; 95% CI: 1.39-19.98; pc= 0.018). CONCLUSION: Our results suggest a potential implication of the VEGF gene -634 G-->C polymorphism in the development of severe ischemic manifestations of GCA.
Blanca Rueda; Miguel A Lopez-Nevot; Maria J Lopez-Diaz; Carlos Garcia-Porrua; Javier Martín; Miguel A Gonzalez-Gay
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  32     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1737-41     Citation Subset:  IM    
Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Cohort Studies
Confidence Intervals
Gene Expression Regulation
Genetic Predisposition to Disease*
Giant Cell Arteritis / diagnosis,  epidemiology,  genetics*
Ischemia / diagnosis,  epidemiology,  genetics*
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Reference Values
Risk Assessment
Sensitivity and Specificity
Temporal Arteries*
Vascular Endothelial Growth Factor A / genetics*
Reg. No./Substance:
0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A

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