Document Detail


A functional variant in ANGPT1 and the risk of pregnancies with hypertensive disorders and small for gestational age infants.
MedLine Citation:
PMID:  22205728     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pregnancies complicated by preeclampsia and small-for-gestational-age (SGA) infants demonstrate impaired placental vascular remodelling. Angiopoietin-1 is an angiogenic growth factor which regulates vascular integrity and remodelling. The TT genotype of angiopoietin 1 (ANGPT1) rs2507800 polymorphism has been associated with increased plasma angiopoietin-1 levels compared to the AA genotype. We aimed to investigate the association between ANGPT1 rs2507800 polymorphism and pregnancies complicated by gestational hypertensive disorders and SGA infants. We also aimed to investigate whether the polymorphism was associated with abnormal uterine artery Doppler as a surrogate marker of impaired placental vascular remodelling. Genotyping data of 1361 nulliparous pregnant women, 1226 partners and 1190 infants were analysed. The prevalence of ANGPT1 rs2507800 TT genotype was reduced in women with preeclampsia (p=0.01, aOR 0.5, 95% CI 0.3-0.9), hypertensive SGA (p=0.04, aOR 0.5, 95% CI 0.2-0.9) and SGA with abnormal uterine artery Doppler (p=0.009, aOR 0.4, 95% CI 0.2-0.8) compared to women with uncomplicated pregnancy. The prevalence of maternal ANGPT1 rs2507800 TT genotype was reduced in women with increased uterine artery resistance index (p=0.03, aOR 0.7, 95% CI 0.5-0.9) and bilateral notching of the uterine arteries (p=0.004, aOR 0.6, 95% CI 0.4-0.9). These results remained significant after correcting for multiple testing. Maternal ANGPT1 rs2507800 TT genotype is associated with a reduced risk for preeclampsia, hypertensive SGA and abnormal uterine artery Doppler. These findings suggest that the TT genotype may protect against these pregnancy disorders by increasing angiopoietin-1 production at the maternal-fetal interface. The ANGPT1 rs2507800 polymorphism may have a potential role in screening women to predict the risk of these pregnancy complications.
Authors:
Prabha H Andraweera; Gustaaf A Dekker; Steven D Thompson; Robyn A North; Lesley M E McCowan; Claire T Roberts;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-28
Journal Detail:
Title:  Molecular human reproduction     Volume:  -     ISSN:  1460-2407     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Discipline of Obstetrics and Gynaecology, Research Centre for Reproductive Health, University of Adelaide, Adelaide, Australia.
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