| A functional screening identifies five microRNAs controlling glypican-3: role of miR-1271 down-regulation in hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 22865282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Using a functional screen, we found that miR-96, miR-129-1-3p, miR-1271, miR-1291, and miR-1303 differentially control GPC3 expression in HCC cells. In a subgroup of HCC, the up-regulation of GPC3 was associated with a concomitant down-regulation of its repressor miR-1271. Therefore, we propose that GPC3 overexpression and its associated oncogenic effects are linked to the down-regulation of miR-1271 in HCC. |
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Authors:
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Marion Maurel; Sandra Jalvy; Yannick Ladeiro; Chantal Combe; Laetitia Vachet; Francis Sagliocco; Paulette Bioulac-Sage; Vincent Pitard; Hélène Jacquemin-Sablon; Jessica Zucman-Rossi; Benoît Laloo; Christophe F Grosset |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 57 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-08 Completed Date: 2013-03-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 195-204 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Association for the Study of Liver Diseases. |
Affiliation:
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University Bordeaux, Physiopathologie du cancer du foie, U1053, F-33000 Bordeaux, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3' Untranslated Regions Carcinoma, Hepatocellular / metabolism* Cell Line, Tumor Gene Expression Regulation, Neoplastic* Glypicans / metabolism* Hepatocytes / metabolism Humans Liver Neoplasms / metabolism* MicroRNAs / metabolism* RNA Processing, Post-Transcriptional |
| Chemical | |
Reg. No./Substance:
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0/3' Untranslated Regions; 0/GPC3 protein, human; 0/Glypicans; 0/MIRN1271 microRNA, human; 0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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