Document Detail


A functional screening identifies five microRNAs controlling glypican-3: role of miR-1271 down-regulation in hepatocellular carcinoma.
MedLine Citation:
PMID:  22865282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Using a functional screen, we found that miR-96, miR-129-1-3p, miR-1271, miR-1291, and miR-1303 differentially control GPC3 expression in HCC cells. In a subgroup of HCC, the up-regulation of GPC3 was associated with a concomitant down-regulation of its repressor miR-1271. Therefore, we propose that GPC3 overexpression and its associated oncogenic effects are linked to the down-regulation of miR-1271 in HCC.
Authors:
Marion Maurel; Sandra Jalvy; Yannick Ladeiro; Chantal Combe; Laetitia Vachet; Francis Sagliocco; Paulette Bioulac-Sage; Vincent Pitard; Hélène Jacquemin-Sablon; Jessica Zucman-Rossi; Benoît Laloo; Christophe F Grosset
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-03-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-204     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
University Bordeaux, Physiopathologie du cancer du foie, U1053, F-33000 Bordeaux, France.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions
Carcinoma, Hepatocellular / metabolism*
Cell Line, Tumor
Gene Expression Regulation, Neoplastic*
Glypicans / metabolism*
Hepatocytes / metabolism
Humans
Liver Neoplasms / metabolism*
MicroRNAs / metabolism*
RNA Processing, Post-Transcriptional
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/GPC3 protein, human; 0/Glypicans; 0/MIRN1271 microRNA, human; 0/MicroRNAs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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