Document Detail


A functional role for transverse (t-) tubules in the atria.
MedLine Citation:
PMID:  23147188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian ventricular myocytes are characterised by the presence of an extensive transverse (t-) tubule network which is responsible for the synchronous rise of intracellular Ca(2+) concentration ([Ca(2+)]i) during systole. Disruption to the ventricular t-tubule network occurs in various cardiac pathologies and leads to heterogeneous changes of [Ca(2+)]i which are thought to contribute to the reduced contractility and increased susceptibility to arrhythmias of the diseased ventricle. Here we review evidence that, despite the long-held dogma of atrial cells having no or very few t-tubules, there is indeed an extensive and functionally significant t-tubule network present in atrial myocytes of large mammals including human. Moreover, the atrial t-tubule network is highly plastic in nature and undergoes far more extensive remodelling in heart disease than is the case in the ventricle with profound consequences for the resulting systolic Ca(2+) transient. In addition to considering the functional role of the t-tubule network in the healthy and diseased atria we also provide an overview of recent data concerning the putative factors controlling the formation of t-tubules and conclude by posing some important questions that currently remain to be addressed and whether or not targeting t-tubules offers potential novel therapeutic possibilities for heart disease.
Authors:
Katharine M Dibb; Jessica D Clarke; David A Eisner; Mark A Richards; Andrew W Trafford
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-09
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  58     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-11-01     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  84-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Calcium / metabolism*
Calcium Signaling*
Heart Atria* / metabolism,  physiopathology
Heart Diseases / metabolism*,  pathology
Heart Ventricles / metabolism,  physiopathology
Humans
Myocytes, Cardiac / metabolism,  pathology
Sarcolemma / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
FS/09/002/26487//British Heart Foundation; FS/12/34/29565//British Heart Foundation; PG/09/062/27872//British Heart Foundation
Chemical
Reg. No./Substance:
SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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