| The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question. | |
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MedLine Citation:
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PMID: 19772872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the fundamental goals in understanding schizophrenia is linking the observable symptoms to the underlying unobservable pathophysiology. Given recent advances in medical imaging, researchers are increasingly investigating brain-behavior relationships to better understand the neural substrates of negative, positive, and disorganization symptoms in schizophrenia. This review focused on 25 task-related functional magnetic resonance imaging studies and found meaningful small to moderate associations between specific symptom dimensions and regional brain activity. Negative symptoms were related to the functioning of the ventrolateral prefrontal cortex and ventral striatum. Positive symptoms, particularly persecutory ideation, were related to functioning of the medial prefrontal cortex, amygdala, and hippocampus/parahippocampal region. Disorganization symptoms, although less frequently evaluated, were related to functioning of the dorsolateral prefrontal cortex. Surprisingly, no symptom domain had a consistent relationship with the middle or superior temporal regions. While a number of adaptations in experimental design and reporting standards can facilitate this work, current neuroimaging approaches appear to provide a number of consistent links between the manifest symptoms of schizophrenia and brain dysfunction. |
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Authors:
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Vina M Goghari; Scott R Sponheim; Angus W MacDonald |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-09-20 |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 34 ISSN: 1873-7528 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-07 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: United States |
Other Details:
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Languages: eng Pagination: 468-86 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Clinical Neuroscience of Schizophrenia (CNS) Laboratory, Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada. vina.m.goghari@ucalgary.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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physiopathology* Brain Mapping Humans Magnetic Resonance Imaging Schizophrenia / physiopathology* Schizophrenic Psychology* |
| Grant Support | |
ID/Acronym/Agency:
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MH18269/MH/NIMH NIH HHS; MH79262/MH/NIMH NIH HHS; R21 MH079262-02/MH/NIMH NIH HHS; R24 MH 069675/MH/NIMH NIH HHS; R24 MH069675-03/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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