Document Detail


A functional magnetic resonance imaging study of language processing and its cognitive correlates in prematurely born children.
MedLine Citation:
PMID:  12456913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Abnormalities in brain structure, cognition, and behavior have been described in children born prematurely. However, no direct in vivo evidence has yet demonstrated abnormal neural processing in these children. Our aim was to compare brain activity associated with phonologic and semantic processing of language between term and preterm children using functional magnetic resonance imaging (fMRI). METHODS: fMRI scans were acquired during a passive language comprehension task in 26 preterm children at 8 years of age and in 13 term community control children who were comparable in age, sex, maternal education, and minority status. IQ was assessed using a standard measure of intelligence. RESULTS: The pattern of brain activity identified in a semantic processing task in the preterm children closely resembled the pattern of brain activity identified in a phonologic processing task in term controls. The greater this resemblance in the preterm children, the lower their verbal comprehension IQ scores and the poorer their language comprehension during the scanning task. CONCLUSIONS: Preterm children with the poorest language comprehension seemed not to fully engage normal semantic processing pathways in a language comprehension task. These children instead engaged pathways that normal term children used to process meaningless phonologic sounds. Aberrant processing of semantic content in these preterm children may account in part for their lower verbal IQ scores.
Authors:
Bradley S Peterson; Betty Vohr; Michael J Kane; Douglas H Whalen; Karen C Schneider; Karol H Katz; Heping Zhang; Charles C Duncan; Robert Makuch; John C Gore; Laura R Ment
Related Documents :
7845413 - Variability in early communicative development.
15282603 - Fine-scale phylogenetic architecture of a complex bacterial community.
11852123 - Epidemiology of chronic suppurative otitis media among saudi children--a comparative st...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  110     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-28     Completed Date:  2002-12-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1153-62     Citation Subset:  AIM; IM    
Affiliation:
Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA. petersob@child.cpmc.columbia.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Benzophenones
Brain / anatomy & histology,  physiology*
Child
Cognition / physiology*
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature / physiology*
Intelligence Tests
Language Development*
Least-Squares Analysis
Magnetic Resonance Imaging*
Male
Phonetics
Reference Values
Semantics
Grant Support
ID/Acronym/Agency:
DC-00493/DC/NIDCD NIH HHS; HD-01994/HD/NICHD NIH HHS; MH01232/MH/NIMH NIH HHS; MH30929/MH/NIMH NIH HHS; MH59139/MH/NIMH NIH HHS; NS 27116/NS/NINDS NIH HHS; NS 35476/NS/NINDS NIH HHS; RR 06022/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Benzophenones; 80859-11-6/G 1026

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Level of prenatal cocaine exposure and scores on the Bayley Scales of Infant Development: modifying ...
Next Document:  Infant mortality among singletons and twins in the United States during 2 decades: effects of matern...