| The functional inhibition of plasma kallikrein. A critical factor in septic shock. | |
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MedLine Citation:
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PMID: 6552854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional kallikrein inhibition and prekallikrein levels have been studied during septic shock and septicemia in 13 patients using chromogenic peptide substrate assays. Eleven septic shock episodes were studied of which 5 were fatal. Marked reductions in functional kallikrein inhibition and prekallikrein values occurred during fatal septic shock. In patients who could be resuscitated from septic shock, functional kallikrein inhibition was in the normal range, but significantly lower than in patients with septicemia only. Also in these two groups of patients decreased prekallikrein values were found. During treatment a gradual increase in prekallikrein was observed in the survivors and functional kallikrein inhibition values remained in the normal range during the whole course. Our results indicate that the functional inhibition of plasma kallikrein plays a major role in determining the outcome of septic shock. |
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Authors:
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N Smith-Erichsen; A O Aasen; E Amundsen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 156 (Pt B) ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1049-54 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Kallikreins / antagonists & inhibitors, metabolism* Sepsis / enzymology Shock, Septic / enzymology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.-/Kallikreins |
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