Document Detail

The functional inhibition of plasma kallikrein. A critical factor in septic shock.
MedLine Citation:
PMID:  6552854     Owner:  NLM     Status:  MEDLINE    
Functional kallikrein inhibition and prekallikrein levels have been studied during septic shock and septicemia in 13 patients using chromogenic peptide substrate assays. Eleven septic shock episodes were studied of which 5 were fatal. Marked reductions in functional kallikrein inhibition and prekallikrein values occurred during fatal septic shock. In patients who could be resuscitated from septic shock, functional kallikrein inhibition was in the normal range, but significantly lower than in patients with septicemia only. Also in these two groups of patients decreased prekallikrein values were found. During treatment a gradual increase in prekallikrein was observed in the survivors and functional kallikrein inhibition values remained in the normal range during the whole course. Our results indicate that the functional inhibition of plasma kallikrein plays a major role in determining the outcome of septic shock.
N Smith-Erichsen; A O Aasen; E Amundsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  156 (Pt B)     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1049-54     Citation Subset:  IM    
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MeSH Terms
Kallikreins / antagonists & inhibitors,  metabolism*
Sepsis / enzymology
Shock, Septic / enzymology*
Reg. No./Substance:
EC 3.4.21.-/Kallikreins

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