Document Detail

A functional and histopathological comparison of proximal and distal saphenous vein contractility and morphology.
MedLine Citation:
PMID:  16392207     Owner:  NLM     Status:  MEDLINE    
Variations in vascular reactivity and morphology of proximal and distal saphenous vein might affect its performance as a bypass conduit. Because peri- or postoperative graft spasm or intimal hyperplasia reduces patency, we compared the reactivity and morphology of human proximal and distal saphenous vein conduits. Isometric tension studies were performed in response to potassium chloride (80 mM), phenylephrine (10(-8) - 10(-5) M), norepinephrine (10(-8) - 10(-5) M), and angiotensin II (10(-11) - 10(-7) M). Relaxant responses were tested with acetylcholine (10(-9) - 10(-5) M), sodium nitroprusside (10(-10) - 10(-6) M), and diltiazem (10(-10) - 10(-4) M). Also, vein segments from proximal and distal leg saphenous vein grafts were collected for histopathologic investigation. In proximal and distal saphenous vein segments, we also examined the structure of intima, media, and adventitia, and we evaluated the smooth muscle cell/extracellular matrix ratio in the media. There was no significant difference (P > 0.05) between proximal and distal venous segments in response to vasoconstrictors or vasodilators. Similarly, investigation by light microscopy was unable to show any significant difference between proximal and distal conduits in vascular structure. The smooth muscle cell/extracellular matrix ratio was also similar in these graft materials. Our failure to find functional or morphologic differences between proximal and distal saphenous vein segments suggests that there is no advantage in using one of these preparations over the other as a conduit in coronary artery bypass operations.
Ilhan Golbasi; Arda Tasatargil; Nazif Hikmet Aksoy; Gulay Sadan; Edibe Karasu; Cengiz Turkay; Omer Bayezid
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  32     ISSN:  0730-2347     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-01-24     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
Department of Cardiovascular Surgery, Akdeniz University, 07070 Antalya, Turkey.
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MeSH Terms
Coronary Artery Bypass
Coronary Disease / surgery
Middle Aged
Potassium Chloride / pharmacology
Saphenous Vein / cytology*,  physiology*,  transplantation
Ultrasonography, Doppler
Vasoconstriction / drug effects,  physiology*
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Vasoconstrictor Agents; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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