| A functional and histopathological comparison of proximal and distal saphenous vein contractility and morphology. | |
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MedLine Citation:
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PMID: 16392207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variations in vascular reactivity and morphology of proximal and distal saphenous vein might affect its performance as a bypass conduit. Because peri- or postoperative graft spasm or intimal hyperplasia reduces patency, we compared the reactivity and morphology of human proximal and distal saphenous vein conduits. Isometric tension studies were performed in response to potassium chloride (80 mM), phenylephrine (10(-8) - 10(-5) M), norepinephrine (10(-8) - 10(-5) M), and angiotensin II (10(-11) - 10(-7) M). Relaxant responses were tested with acetylcholine (10(-9) - 10(-5) M), sodium nitroprusside (10(-10) - 10(-6) M), and diltiazem (10(-10) - 10(-4) M). Also, vein segments from proximal and distal leg saphenous vein grafts were collected for histopathologic investigation. In proximal and distal saphenous vein segments, we also examined the structure of intima, media, and adventitia, and we evaluated the smooth muscle cell/extracellular matrix ratio in the media. There was no significant difference (P > 0.05) between proximal and distal venous segments in response to vasoconstrictors or vasodilators. Similarly, investigation by light microscopy was unable to show any significant difference between proximal and distal conduits in vascular structure. The smooth muscle cell/extracellular matrix ratio was also similar in these graft materials. Our failure to find functional or morphologic differences between proximal and distal saphenous vein segments suggests that there is no advantage in using one of these preparations over the other as a conduit in coronary artery bypass operations. |
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Authors:
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Ilhan Golbasi; Arda Tasatargil; Nazif Hikmet Aksoy; Gulay Sadan; Edibe Karasu; Cengiz Turkay; Omer Bayezid |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital Volume: 32 ISSN: 0730-2347 ISO Abbreviation: Tex Heart Inst J Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-05 Completed Date: 2006-01-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8214622 Medline TA: Tex Heart Inst J Country: United States |
Other Details:
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Languages: eng Pagination: 287-93 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Akdeniz University, 07070 Antalya, Turkey. Golbasi@akdeniz.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Bypass Coronary Disease / surgery Female Humans Male Middle Aged Potassium Chloride / pharmacology Saphenous Vein / cytology*, physiology*, transplantation Ultrasonography, Doppler Vasoconstriction / drug effects, physiology* Vasoconstrictor Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 7447-40-7/Potassium Chloride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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