Document Detail


A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans.
MedLine Citation:
PMID:  16221767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Slow, rhythmic oscillations (<5 Hz) in the sleep electroencephalogram may be a sign of synaptic plasticity occurring during sleep. The oscillations, referred to as slow-wave activity (SWA), reflect sleep need and sleep intensity. The amount of SWA is homeostatically regulated. It is enhanced after sleep loss and declines during sleep. Animal studies suggested that sleep need is genetically controlled, yet the physiological mechanisms remain unknown. Here we show in humans that a genetic variant of adenosine deaminase, which is associated with the reduced metabolism of adenosine to inosine, specifically enhances deep sleep and SWA during sleep. In contrast, a distinct polymorphism of the adenosine A(2A) receptor gene, which was associated with interindividual differences in anxiety symptoms after caffeine intake in healthy volunteers, affects the electroencephalogram during sleep and wakefulness in a non-state-specific manner. Our findings indicate a direct role of adenosine in human sleep homeostasis. Moreover, our data suggest that genetic variability in the adenosinergic system contributes to the interindividual variability in brain electrical activity during sleep and wakefulness.
Authors:
J V Rétey; M Adam; E Honegger; R Khatami; U F O Luhmann; H H Jung; W Berger; H-P Landolt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-12
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  102     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-26     Completed Date:  2005-12-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15676-81     Citation Subset:  IM    
Affiliation:
Institute of Pharmacology and Toxicology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Deaminase / genetics*
Adult
Electroencephalography
Female
Genetic Variation
Genotype
Humans
Male
Sleep / genetics*,  physiology
Time Factors
Chemical
Reg. No./Substance:
EC 3.5.4.4/Adenosine Deaminase
Comments/Corrections

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