Document Detail


The functional evolution of GALT: a review.
MedLine Citation:
PMID:  10897470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This synopsis of the evolution of gut-associated lymphoid tissue (GALT) in increasingly complex animals suggests that GALT plays an essential role in cellular nutrition and energy metabolism as well as in immunity. Throughout phylogeny, the mediation of immunity as well as cell nutrition depends on the normal capacity of GALT to produce lymphocytes which customarily generate an evolving variety of soluble globulins during maturation and proceed to migrate throughout the body as emperipoletic cytoplasm-depleted cells which donate their residual constituents to genetically compatible cells; and destroy living matter recognized as genetically incompatible. A dividend is that the lymphocytes not only destroy the genetically foreign but also render the remains innocuous or useful as food.
Authors:
J W Shields
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lymphology     Volume:  33     ISSN:  0024-7766     ISO Abbreviation:  Lymphology     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-01     Completed Date:  2000-11-01     Revised Date:  2006-11-03    
Medline Journal Info:
Nlm Unique ID:  0155112     Medline TA:  Lymphology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-57     Citation Subset:  IM    
Affiliation:
Santa Barbara, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Digestive System / cytology*
Evolution*
Humans
Lymphoid Tissue* / embryology,  immunology,  physiology
Phylogeny

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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