Document Detail

A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine.
MedLine Citation:
PMID:  1909444     Owner:  NLM     Status:  MEDLINE    
H.M. van Praag has been suggesting a reappraisal of syndromes in psychiatry for over 20 years. He has tried to define syndromes originating from the same biochemical disorder. He has denoted this concept as 'functional psychopathology'. As an example of such a functional syndrome, he has cited the serotonin-shortage syndrome which unifies various psychiatric symptoms under a new point of view. The treatment of the serotonin-shortage syndrome is best served by psychopharmaca which raise the metabolism of serotonin in the synaptic cleft, e.g. the selective serotonin re-uptake inhibitors. Borrowing F. Freyhan's concept of 'target symptoms', one can now speak of 'functional target syndromes', within the frame of functional psychopathology.
W Pöldinger; B Calanchini; W Schwarz
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopathology     Volume:  24     ISSN:  0254-4962     ISO Abbreviation:  Psychopathology     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-07     Completed Date:  1991-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8401537     Medline TA:  Psychopathology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  53-81     Citation Subset:  IM    
Psychiatrische Universitätsklinik, Basel, Schweiz.
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MeSH Terms
5-Hydroxytryptophan / adverse effects,  therapeutic use*
Aged, 80 and over
Antidepressive Agents*
Brain / drug effects,  physiopathology
Depressive Disorder / drug therapy*,  physiopathology,  psychology
Double-Blind Method
Middle Aged
Oximes / adverse effects,  therapeutic use*
Psychiatric Status Rating Scales
Receptors, Serotonin / drug effects,  physiology
Serotonin / deficiency*,  physiology
Serotonin Antagonists*
Reg. No./Substance:
0/Antidepressive Agents; 0/Oximes; 0/Receptors, Serotonin; 0/Serotonin Antagonists; 50-67-9/Serotonin; 54739-18-3/Fluvoxamine; 56-69-9/5-Hydroxytryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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