| The functional border zone in conscious dogs. | |
| | |
MedLine Citation:
|
PMID: 3652427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Studies focusing on the functional border zone have been performed largely with anesthetized, open-chest preparations. Therefore, we instrumented 14 dogs at sterile surgery with sonomicrometers arrayed to measure systolic wall thickening across the perfusion boundary produced by circumflex coronary occlusion. We fitted sigmoid curves to the data to model the distribution of wall thickening impairment as a function of distance from the perfusion boundary, which was delineated with myocardial blood flow (15 micron diameter microspheres) maps. Using this approach, we defined the functional border zone as the distance from the perfusion boundary to 97.5% of the sigmoid curve's nonischemic asymptote. The lateral extent of the functional border zone, measured 10 min and 3 hr after occlusion, was 32 and 28 degrees of circumference, respectively. To evaluate the severity of nonischemic dysfunction, we measured average systolic wall thickening within the functional border zone. It was reduced from 3.69 +/- 1.10 (mean +/- SD) mm to 2.98 +/- 1.07 mm (p less than .01) and 2.74 +/- 1.12 mm (p less than .01) early and late after coronary occlusion. Thus, a narrow functional border zone was evident during circumflex coronary occlusion in conscious dogs. Its lateral extent was limited to approximately 30 degrees (similar to findings in open-chest, anesthetized dogs), severe dysfunction was restricted to the immediate vicinity of the perfusion boundary, and the average severity of nonischemic dysfunction within the functional border zone was mild. |
| | |
Authors:
|
K P Gallagher; R A Gerren; X H Ning; S P McManimon; M C Stirling; M Shlafer; A J Buda |
Related Documents
:
|
1860227 - Instantaneous hyperemic flow-versus-pressure slope index. microsphere validation of an ... 12702737 - The effect of dehydroepiandrosterone on coronary blood flow in prepubertal anaesthetize... 8809167 - Synthesis and selective coronary vasodilatory activity of 3,4-dihydro-2,2-bis(methoxyme... 2180577 - Comparison of meglumine sodium diatrizoate, iopamidol, and iohexol for coronary angiogr... 11669407 - Autonomic and hemodynamic effects of a new selective dopamine agonist, chf1035, in pati... 2388667 - Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation Volume: 76 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1987 Oct |
Date Detail:
|
Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 929-42 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery (Thoracic Section), University of Michigan Medical School, Ann Arbor 48109. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Flow Velocity Coronary Circulation Coronary Disease / pathology, physiopathology* Dogs Electrocardiography Heart / physiopathology* Hemodynamics Models, Cardiovascular* Myocardial Contraction Myocardium / pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
KO4 HL04120/HL/NHLBI NIH HHS; R01 HL29716/HL/NHLBI NIH HHS; R01 HL32043/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulation of vascular capacitance by angiotensin and nitroprusside: a mechanism of changes in peric...
Next Document: The physiologic basis of dobutamine as compared with dipyridamole stress interventions in the assess...