Document Detail


The functional architecture of dehydration-anorexia.
MedLine Citation:
PMID:  20399797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anorexia that accompanies the drinking of hypertonic saline (DE-anorexia) is a critical adaptive behavioral mechanism that helps protect the integrity of fluid compartments during extended periods of cellular dehydration. Feeding is rapidly reinstated once drinking water is made available again. The relative simplicity and reproducibility of these behaviors makes DE-anorexia a very useful model for investigating how the various neural networks that control ingestive behaviors first suppress and then reinstate feeding. We show that DE-anorexia develops primarily because the mechanisms that terminate ongoing meals are upregulated in such a way as to significantly reduce meal size. At the same time however, signals generated by the ensuing negative energy balance appropriately activate neural mechanisms that can increase food intake. But as the output from these two competing processes is integrated, the net result is an increasing reduction of nocturnal food intake, despite the fact that spontaneous meals are initiated with the same frequency as in control animals. Furthermore, hypothalamic NPY injections also stimulate feeding in DE-anorexic animals with the same latency as controls, but again meals are prematurely terminated. Comparing Fos expression patterns across the brain following 2-deoxyglucose administration to control and DE-anorexic animals implicates neurons in the descending part of the parvicellular paraventricular nucleus of the hypothalamus and the lateral hypothalamic areas as key components of the networks that control DE-anorexia. Finally, DE-anorexia generates multiple inhibitory processes to suppress feeding. These are differentially disengaged once drinking water is reinstated. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.
Authors:
Alan G Watts; Christina N Boyle
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-23
Journal Detail:
Title:  Physiology & behavior     Volume:  100     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-09-16     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-7     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / classification,  complications*,  pathology
Dehydration / complications*,  pathology
Disease Models, Animal
Drinking Behavior / drug effects,  physiology*
Feeding Behavior / drug effects,  physiology*
Humans
Models, Neurological
Nerve Net / pathology,  physiopathology
Neural Pathways / pathology,  physiopathology
Saline Solution, Hypertonic / administration & dosage
Grant Support
ID/Acronym/Agency:
R01 MH066168/MH/NIMH NIH HHS; R01 MH066168-07/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Saline Solution, Hypertonic
Comments/Corrections

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