| The function of secretory IgA in the context of the intestinal continuum of adaptive immune responses in host-microbial mutualism. | |
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MedLine Citation:
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PMID: 22138187 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The large production of immunoglobulin (Ig)A is energetically costly. The fact that evolution retained this apparent luxury of intestinal class switch recombination to IgA within the human population strongly indicates that there must be a critical specific function of IgA for survival of the species. The function of IgA has been investigated in a series of different models that will be discussed here. While IgA has clear protective functions against toxins or in the context of intestinal viral infections, the function of IgA specific for non-pathogenic commensal bacteria remains unclear. In the context of the current literature we present a hypothesis where secretory IgA integrates as an additional layer of immune function into the continuum of intestinal CD4 T cell responses, to achieve a mutualistic relationship between the intestinal commensal microbiota and the host. |
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Authors:
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M B Geuking; K D McCoy; A J Macpherson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
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Title: Seminars in immunology Volume: - ISSN: 1096-3618 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Maurice Müller Laboratories, DKF, Universitätsklinik für Viszerale Chirurgie und Medizin, University Hospital (Inselspital), Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. |
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