Document Detail


The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming.
MedLine Citation:
PMID:  25173869     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The process that converts somatic cells to pluripotent ones has enormous potential not only as a tool to generate cells for disease therapy and modeling, but also as an experimental system to investigate fundamental biological questions. The discovery of mesenchymal-to-epithelial transitions at the initial phase of reprogramming provides a conceptual framework to understand reprogramming in a cellular context and it helps to resolve the mechanistic roles of the original Yamanaka factors as well as newly identified modulators of reprogramming. Emerging concept such as sequential EMT-MET in reprogramming further suggests the value of this model to the understanding of cell fate conversions. We highlight recent advances about the function and regulation of MET in reprogramming and discuss their potential implications here.
Authors:
Xiaodong Shu; Duanqing Pei
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Publication Detail:
Type:  REVIEW     Date:  2014-8-28
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  28C     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  32-37     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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