Document Detail

On the function of placental corticotropin-releasing hormone: a role in maternal-fetal conflicts over blood glucose concentrations.
MedLine Citation:
PMID:  22564253     Owner:  NLM     Status:  Publisher    
Throughout the second and third trimesters, the human placenta (and the placenta in other anthropoid primates) produces substantial quantities of corticotropin-releasing hormone (placental CRH), most of which is secreted into the maternal bloodstream. During pregnancy, CRH concentrations rise over 1000-fold. The advantages that led selection to favour placental CRH production and secretion are not yet fully understood. Placental CRH stimulates the production of maternal adrenocorticotropin hormone (ACTH) and cortisol, leading to substantial increases in maternal serum cortisol levels during the third trimester. These effects are puzzling in light of widespread theory that cortisol has harmful effects on the fetus. The maternal hypothalamic-pituitary-adrenal (HPA) axis becomes less sensitive to cortisol during pregnancy, purportedly to protect the fetus from cortisol exposure. Researchers, then, have often looked for beneficial effects of placental CRH that involve receptors outside the HPA system, such as the uterine myometrium (e.g. the placental clock hypothesis). An alternative view is proposed here: the beneficial effect of placental CRH to the fetus lies in the fact that it does stimulate the production of cortisol, which, in turn, leads to greater concentrations of glucose in the maternal bloodstream available for fetal consumption. In this view, maternal HPA insensitivity to placental CRH likely reflects counter-adaptation, as the optimal rate of cortisol production for the fetus exceeds that for the mother. Evidence pertaining to this proposal is reviewed.
Steven W Gangestad; Ann E Caldwell Hooper; Melissa A Eaton
Related Documents :
6578773 - Partial hydatidiform mole: ultrasonographic features.
2418683 - Occurrence of molar pregnancy in patients undergoing elective abortion: comparison with...
23914893 - Treatment of dermatologic connective tissue disease and autoimmune blistering disorders...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-8
Journal Detail:
Title:  Biological reviews of the Cambridge Philosophical Society     Volume:  -     ISSN:  1469-185X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0414576     Medline TA:  Biol Rev Camb Philos Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Biological Reviews © 2012 Cambridge Philosophical Society.
Department of Psychology, University of New Mexico, Albuquerque, NM 87111, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A centralised electronic Multidrug-Resistant Tuberculosis Advisory Service: the first 2 years.
Next Document:  Pustular psoriasis precipitated by cytomegalovirus infection.