| The function of glucocorticoids in thermogenesis. | |
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MedLine Citation:
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PMID: 446769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies both in vivo and in vitro implicate glucocorticoids in various aspects of thermogenesis and prevention of heat loss. Many or most of these effects are probably permissive. Adrenalectomized, cold-exposed rats require glucocorticoids for catecholamine-mediated mobilization of free fatty acids, for shivering responses, and for vasoconstriction and piloerection. Glucocorticoid pretreatment of hypothermic hamsters results in a physiological state more similar bioenergetically to hibernation than to hypothermia. For example, such hamsters can arouse to normothermia from a body temperature of 8 C in a 7--8 C cold room. Lipolytic, gluconeogenic, glycogenolic, and pressor actions resulting from several hormone interactions that require glucocorticoids for optimum responses may account for the enhanced thermogenic ability shown by glucocorticoid-pretreated hamsters. Glucocorticoid treatment also results in enhanced blood and liver carbohydrate levels during hypothermia, a condition similar to that occurring in naturally hibernating animals as opposed to the depleted carbohydrate reserves generally seen in hypothermic animals. |
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Authors:
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D R Deavers; X J Musacchia |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Federation proceedings Volume: 38 ISSN: 0014-9446 ISO Abbreviation: Fed. Proc. Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-09-01 Completed Date: 1979-09-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372771 Medline TA: Fed Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2177-81 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Adrenal Glands / physiology* Adrenalectomy Animals Body Temperature Regulation* / drug effects Catecholamines / physiology Cold Temperature Cricetinae Glucocorticoids / pharmacology, physiology* Gluconeogenesis / drug effects Glycogen / metabolism Lipid Mobilization Rats |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Glucocorticoids; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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