| The frequent use of oral retinoids in combination with other treatments for psoriasis: a retrospective analysis. | |
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MedLine Citation:
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PMID: 15988549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Combination treatment in psoriasis may be common, logical, and appropriate, even if not well tested or well documented by clinical trials. While oral retinoids such as acitretin can be used as monotherapy, efficacy can be further augmented by combination use with other agents. Similarly, because of its safety profile, acitretin can be added in low doses to help patients who have not achieved adequate control with other psoriasis treatments. OBJECTIVE: The purpose of this study was to assess how oral retinoids are used in combination with other drugs to treat psoriasis. METHODS: We assessed the use of acitretin and other oral retinoids for the treatment of psoriasis using two sources of information: nationally representative survey data from the National Ambulatory Medical Care Survey (NAMCS) and local data obtained by chart review of 518 patients seen in a university dermatology clinic. RESULTS: In the NAMCS, oral retinoids were prescribed with other psoriasis medications at 71% of visits. In the chart review, combination use was even more frequent (96% of subjects were on combination treatment) and included combinations of acitretin with topicals, phototherapy, and other systemic treatments. Adverse events were reported in 53% of patients treated with acitretin, although none were severe. CONCLUSION: Use of acitretin in combination with many other psoriasis treatments is a common practice. Mucocutaneous side effects of oral retinoids are common but with appropriate dosing are generally mild. |
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Authors:
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Judy Hu; Rajesh Balkrishnan; Fabian Camacho; Wei Lang; Daniel J Pearce; Alan B Fleischer; Steven R Feldman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cutaneous medicine and surgery Volume: 8 ISSN: 1203-4754 ISO Abbreviation: J Cutan Med Surg Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2005-09-28 Completed Date: 2005-12-13 Revised Date: 2007-07-04 |
Medline Journal Info:
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Nlm Unique ID: 9614685 Medline TA: J Cutan Med Surg Country: United States |
Other Details:
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Languages: eng Pagination: 411-4 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157 1071, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acitretin
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administration & dosage* Administration, Oral Dermatologic Agents / administration & dosage* Drug Therapy, Combination Female Humans Male Middle Aged Psoriasis / drug therapy* Retinoids / administration & dosage* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Retinoids; 55079-83-9/Acitretin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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