| The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial. | |
| | |
MedLine Citation:
|
PMID: 21242996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence in situ hybridization analyses-in a three-step manner-using probes for: (i) CDKN2A at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87; P=0.002) and high hyperdiploidy (0.82; P=0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality. |
| | |
Authors:
|
V Zachariadis; F Gauffin; E Kuchinskaya; M Heyman; J Schoumans; E Blennow; B Gustafsson; G Barbany; I Golovleva; H Ehrencrona; L Cavelier; L Palmqvist; G Lönnerholm; M Nordenskjöld; B Johansson; E Forestier; A Nordgren; ; |
Related Documents
:
|
22934286 - Comparative cost-effectiveness of stereotactic body radiation therapy versus intensity-... 3013106 - Primary chest wall tumors: factors affecting survival. 3580796 - Secondary arterio-enteric fistulae: a surgical challenge. 6308356 - Treatment of modified stage ii (t1 n1 m0, t2 n1 m0) non-small cell bronchogenic carcino... 22934286 - Comparative cost-effectiveness of stereotactic body radiation therapy versus intensity-... 23570666 - The impact of possum score on long-term outcome of patients with rectal cancer. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-18 |
Journal Detail:
|
Title: Leukemia Volume: 25 ISSN: 1476-5551 ISO Abbreviation: Leukemia Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-13 Completed Date: 2011-06-09 Revised Date: 2013-03-04 |
Medline Journal Info:
|
Nlm Unique ID: 8704895 Medline TA: Leukemia Country: England |
Other Details:
|
Languages: eng Pagination: 622-8 Citation Subset: IM |
Affiliation:
|
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Child Child, Preschool Chromosome Aberrations Chromosome Banding Chromosomes, Human, Pair 20 / genetics* Chromosomes, Human, Pair 9 / genetics* Female Humans In Situ Hybridization, Fluorescence Infant Karyotyping Male Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics* Prognosis Survival Rate Translocation, Genetic / genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activ...
Next Document: Measuring the effect of incremental angles of wheelchair tilt on interface pressure among individual...