Document Detail


The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial.
MedLine Citation:
PMID:  21242996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevalence is hence unknown. We performed interphase fluorescence in situ hybridization analyses-in a three-step manner-using probes for: (i) CDKN2A at 9p21, (ii) 20p and 20q subtelomeres and (iii) cen9 and cen20. Out of 1033 BCP ALLs diagnosed from 2001 to 2006, 533 were analyzed; 16% (84/533) displayed 9p21 deletions, of which 30% (25/84) had dic(9;20). Thus, dic(9;20)-positivity was found in 4.7% (25/533), making it the third most common genetic subgroup after high hyperdiploidy and t(12;21)(p13;q22). The dic(9;20) was associated with a female predominance and an age peak at 3 years; 18/25 (72%) were allocated to non-standard risk treatment at diagnosis. Including cases detected by G-banding alone, 29 dic(9;20)-positive cases were treated according to the NOPHO ALL 2000 protocol. Relapses occurred in 24% (7/29) resulting in a 5-year event-free survival of 0.69, which was significantly worse than for t(12;21) (0.87; P=0.002) and high hyperdiploidy (0.82; P=0.04). We conclude that dic(9;20) is twice as common as previously surmised, with many cases going undetected by G-banding analysis, and that dic(9;20) should be considered a non-standard risk abnormality.
Authors:
V Zachariadis; F Gauffin; E Kuchinskaya; M Heyman; J Schoumans; E Blennow; B Gustafsson; G Barbany; I Golovleva; H Ehrencrona; L Cavelier; L Palmqvist; G Lönnerholm; M Nordenskjöld; B Johansson; E Forestier; A Nordgren; ;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-18
Journal Detail:
Title:  Leukemia     Volume:  25     ISSN:  1476-5551     ISO Abbreviation:  Leukemia     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-13     Completed Date:  2011-06-09     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  622-8     Citation Subset:  IM    
Affiliation:
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Chromosome Aberrations
Chromosome Banding
Chromosomes, Human, Pair 20 / genetics*
Chromosomes, Human, Pair 9 / genetics*
Female
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Prognosis
Survival Rate
Translocation, Genetic / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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