Document Detail

The frequency of molecular detection of virulence genes encoding cytolysin A, high-pathogenicity island and cytolethal distending toxin of Escherichia coli in cases of sudden infant death syndrome does not differ from that in other infant deaths and healthy infants.
MedLine Citation:
PMID:  19208875     Owner:  NLM     Status:  MEDLINE    
Consistent pathological findings in sudden infant death syndrome (SIDS) are seen which display similarities to the pathogenesis of toxaemic shock and/or sepsis. A key candidate infectious agent that is possibly involved is Escherichia coli, given its universal early colonization of the intestinal tract of infants and an increased frequency of toxigenic and mouse-lethal isolates from SIDS compared with comparison infants. An explanation for these findings has yet to be identified. Using PCR, we screened E. coli isolates from 145 SIDS and 101 dead control and healthy infants for three new candidate pathogenicity-related genes: clyA (cytolysin A), irp2 [high-pathogenicity island (HPI)-specific gene] and cdt (cytolethal distending toxin). The results failed to show a positive correlation with SIDS, instead proving that clyA and irp2 genes were common to the infant intestinal E. coli. Interestingly we observed a high rate of carriage of these two potentially pathogenic genes in E. coli from healthy infants in the absence of diarrhoeal disease, and we report that in a number of cases, the detection of HPI-specific genes was predictable by serotype. Despite the lack of associations defined so far, there remains the likelihood that genetic determinants influence the interactions between E. coli and the host, so these factors may be part of the multi-factorial aspect of SIDS.
Amanda R Highet; Anne M Berry; Karl A Bettelheim; Paul N Goldwater
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  58     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-03-26     Revised Date:  2011-05-27    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
Department of Microbiology and Infectious Diseases, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
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MeSH Terms
Bacterial Outer Membrane Proteins
Bacterial Proteins / genetics
Bacterial Toxins / genetics
Case-Control Studies
Escherichia coli / classification,  genetics,  isolation & purification*,  pathogenicity
Escherichia coli Infections / complications,  mortality*
Escherichia coli Proteins / genetics
Genomic Islands / genetics
Hemolysin Proteins / genetics
Iron-Binding Proteins
Periplasmic Binding Proteins
Polymerase Chain Reaction
Sudden Infant Death / etiology*
Virulence Factors / genetics*
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins; 0/Bacterial Proteins; 0/Bacterial Toxins; 0/Escherichia coli Proteins; 0/Hemolysin Proteins; 0/Iron-Binding Proteins; 0/Periplasmic Binding Proteins; 0/Virulence Factors; 0/cytolethal distending toxin; 0/hlyE protein, E coli

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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