Document Detail


The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats.
MedLine Citation:
PMID:  12093098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
H-Tx rats have fetal-onset inherited hydrocephalus. Linkage analysis has determined the genetics is complex, with at least three loci associated with hydrocephalus. In addition, maternal and/or intrauterine factors influence the frequency of expression. The aim of this study was to characterize nongenetic (epigenetic) factors that affect hydrocephalus in this strain. Groups of primiparous and multiparous females were used to breed fetuses for examination in utero. Multiparous females were manipulated to have either gestation with lactation or, by removal of pups at birth, gestation without lactation. In addition, hydrocephalus expression in postnatal rats from the breeding colony was analyzed for primiparous and multiparous females. The latter were subdivided according to the interval between the litter examined and the previous litter. There was no particular uterine position or horn that favored hydrocephalus and hydrocephalic fetuses were the same weight as normal littermates. The frequency of hydrocephalus was 16-20% in primiparous females and twofold higher in multiparous females that were lactating during pregnancy. Removal of the suckling pups prevented this increase. The severity of hydrocephalus was measured on 1-mm-thick fixed brain slices. Fetuses from lactating females had hydrocephalus that was significantly more severe than the nonlactating groups. However, all fetus groups had hydrocephalus that was very much less severe than the postnatal pups, suggesting that severity increases after birth. It is concluded that there is an epigenetic factor that increases the frequency of inherited hydrocephalus in fetuses if suckling pups are present during gestation. Future experiments will examine possible mechanisms for this genotype-environment interaction.
Authors:
Hazel C Jones; Jamie S Depelteau; Barbara J Carter; Kathleen C Somera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  176     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-08-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-20     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, 32610
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology,  pathology*
Disease Models, Animal
Female
Fetal Weight
Fetus / abnormalities,  pathology
Hydrocephalus / etiology*,  pathology
Lactation*
Maternal Age
Parity*
Pregnancy
Rats
Rats, Inbred Strains
Severity of Illness Index
Specific Pathogen-Free Organisms
Uterus* / pathology
Grant Support
ID/Acronym/Agency:
NS40359/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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