Document Detail

The frequency, impact, and management of mitral regurgitation in patients with heart failure.
MedLine Citation:
PMID:  17543250     Owner:  NLM     Status:  MEDLINE    
Management of severe chronic mitral regurgitation (MR) in severe heart failure is challenging. There are controversies over the efficacy of surgical correction of MR in the presence of severely depressed left ventricular (LV) function. The etiology of MR plays an important role in clinical decision making. In organic MR, surgical correction should be performed even if patients have an LV ejection fraction of less than or equal to 30%. In functional MR, treatment of myocardial damage should be considered as the priority. The long-term mortality benefit of surgical correction of functional MR associated with severe LV dysfunction caused by cardiomyopathy (ischemic or dilated) likely depends on whether myocardial dysfunction can be reversed or improved by treatments (eg, coronary artery revascularization, pharmacologic treatment). Preoperative examination of viable myocardium (ischemic and hibernating myocardium) helps to identify a surgical candidate with ischemic MR associated with ischemic cardiomyopathy. The role of device treatment of MR in heart failure needs further investigation with outcome data.
Min Pu
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  8     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2006 May 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-31     Citation Subset:  IM    
Heart and Vascular Institute, H047, Penn State University, College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, PO Box 850, Hershey, PA 17033, USA.
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MeSH Terms
Cardiac Pacing, Artificial
Cardiac Surgical Procedures
Heart Catheterization
Heart Failure / complications*,  epidemiology,  physiopathology,  therapy*
Mitral Valve Insufficiency / epidemiology,  etiology*,  physiopathology,  therapy*
Stroke Volume
Ventricular Dysfunction, Left / complications,  physiopathology,  therapy
Ventricular Remodeling

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