| The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 1727235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dilated cardiomyopathy is characterized by an increase in ventricular size and impairment of ventricular function. Most cases are believed to be sporadic, and familial dilated cardiomyopathy is usually considered to be a rare and distinct disorder. We studied the proportion of cases of idiopathic dilated cardiomyopathy that were familial in a large sequential series of patients whose first-degree relatives were investigated regardless of whether these relatives had cardiac symptoms. METHODS: We studied relatives of 59 index patients with idiopathic dilated cardiomyopathy of obtaining a family history and performing a physical examination, electrocardiography, and two-dimensional, M-mode, and Doppler echocardiography. A total of 315 relatives were examined. RESULTS: Eighteen relatives from 12 families were shown to have dilated cardiomyopathy. Thus, 12 of the 59 index patients (20.3 percent) had familial disease. There was no difference in age, sex, severity of disease, exposure to selected environmental factors, or electrocardiographic or echocardiographic features between the index patients with familial disease and those with nonfamilial disease. A noteworthy finding was that 22 of 240 healthy relatives (9.2 percent) with normal ejection fractions had increased left ventricular diameters during systole or diastole (or both), as compared with 2 of 112 healthy control subjects (1.8 percent) who were studied separately. CONCLUSIONS: Dilated cardiomyopathy was found to be familial in at least one in five of the patients in this study, a considerably higher percentage than in previous reports. This finding has important implications for family screening and provides direction for further investigation into the causes and natural history of dilated cardiomyopathy. |
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Authors:
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V V Michels; P P Moll; F A Miller; A J Tajik; J S Chu; D J Driscoll; J C Burnett; R J Rodeheffer; J H Chesebro; H D Tazelaar |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 326 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-01-10 Completed Date: 1992-01-10 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: AIM; IM |
Affiliation:
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Department of Medical Genetics, Mayo Clinic, Rochester, Minn. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiomyopathy, Dilated / diagnosis, genetics*, physiopathology Echocardiography Echocardiography, Doppler Electrocardiography Family Female Humans Male Middle Aged Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL36879/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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