| The frequency of cardiac valvular regurgitation in Parkinson's disease. | |
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MedLine Citation:
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PMID: 18398916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the frequency of cardiac valve regurgitation related with low dose dopamine agonists in patients with Parkinson's disease (PD), echocardiograms were analyzed in 527 consecutive PD patients (448 patients treated with dopamine agonists, 79 patients never treated with dopamine agonists as age-matched controls). The frequency of mild or above mild regurgitation of the aortic valve (AR) was significantly higher in the cabergoline group (13.7%, P < 0.05) compared with the controls (2.5%). Odds ratio adjusted by age and sex for AR was significantly higher in the cabergoline group (OR, 6.45; 95% CI, 1.46-28.60; P = 0.01): odds ratio was significantly higher in patients treated with higher daily doses (OR, 14.41; 95% CI, 3.08-67.38; P = 0.0007) and higher cumulative doses (OR, 15.29; 95% CI, 3.19-73.18; P = 0.0006). No statistical difference was identified in the frequency of the tricuspid and mitral regurgitation. None of the other dopamine agonist groups including pergolide gave higher frequency or higher odds ratio compared with the controls. None of our patients showed severe regurgitation or was operated for valvular heart disease. The question as to whether or not longer duration of low dose dopamine agonist treatment would yield the same results needs further studies. |
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Authors:
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Kazuo Yamashiro; Miki Komine-Kobayashi; Taku Hatano; Takao Urabe; Hideki Mochizuki; Nobutaka Hattori; Yoshitaka Iwama; Hiroyuki Daida; Michi Sakai; Takeo Nakayama; Yoshikuni Mizuno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 23 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 935-41 Citation Subset: IM |
Affiliation:
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Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. kazuo-y@med.juntendo.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Valve Insufficiency / chemically induced, epidemiology Azepines / adverse effects, therapeutic use Benzothiazoles / adverse effects, therapeutic use Bromocriptine / adverse effects, therapeutic use Dopamine Agonists / adverse effects, therapeutic use Ergolines / adverse effects, therapeutic use Female Humans Male Mitral Valve Insufficiency / chemically induced, epidemiology* Parkinson Disease / drug therapy, epidemiology* Pergolide / adverse effects, therapeutic use Prevalence |
| Chemical | |
Reg. No./Substance:
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0/Azepines; 0/Benzothiazoles; 0/Dopamine Agonists; 0/Ergolines; 104632-26-0/pramipexol; 25614-03-3/Bromocriptine; 36085-73-1/talipexole; 66104-22-1/Pergolide; 81409-90-7/cabergoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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