Document Detail

The frequency of cardiac valvular regurgitation in Parkinson's disease.
MedLine Citation:
PMID:  18398916     Owner:  NLM     Status:  MEDLINE    
To investigate the frequency of cardiac valve regurgitation related with low dose dopamine agonists in patients with Parkinson's disease (PD), echocardiograms were analyzed in 527 consecutive PD patients (448 patients treated with dopamine agonists, 79 patients never treated with dopamine agonists as age-matched controls). The frequency of mild or above mild regurgitation of the aortic valve (AR) was significantly higher in the cabergoline group (13.7%, P < 0.05) compared with the controls (2.5%). Odds ratio adjusted by age and sex for AR was significantly higher in the cabergoline group (OR, 6.45; 95% CI, 1.46-28.60; P = 0.01): odds ratio was significantly higher in patients treated with higher daily doses (OR, 14.41; 95% CI, 3.08-67.38; P = 0.0007) and higher cumulative doses (OR, 15.29; 95% CI, 3.19-73.18; P = 0.0006). No statistical difference was identified in the frequency of the tricuspid and mitral regurgitation. None of the other dopamine agonist groups including pergolide gave higher frequency or higher odds ratio compared with the controls. None of our patients showed severe regurgitation or was operated for valvular heart disease. The question as to whether or not longer duration of low dose dopamine agonist treatment would yield the same results needs further studies.
Kazuo Yamashiro; Miki Komine-Kobayashi; Taku Hatano; Takao Urabe; Hideki Mochizuki; Nobutaka Hattori; Yoshitaka Iwama; Hiroyuki Daida; Michi Sakai; Takeo Nakayama; Yoshikuni Mizuno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  23     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-08-14     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  935-41     Citation Subset:  IM    
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Aortic Valve Insufficiency / chemically induced,  epidemiology
Azepines / adverse effects,  therapeutic use
Benzothiazoles / adverse effects,  therapeutic use
Bromocriptine / adverse effects,  therapeutic use
Dopamine Agonists / adverse effects,  therapeutic use
Ergolines / adverse effects,  therapeutic use
Mitral Valve Insufficiency / chemically induced,  epidemiology*
Parkinson Disease / drug therapy,  epidemiology*
Pergolide / adverse effects,  therapeutic use
Reg. No./Substance:
0/Azepines; 0/Benzothiazoles; 0/Dopamine Agonists; 0/Ergolines; 25614-03-3/Bromocriptine; 66104-22-1/Pergolide; 7AM2J46Z1Y/talipexole; 83619PEU5T/pramipexole; LL60K9J05T/cabergoline

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