| The frequency of aneuploidy in the secondary spermatocytes of normal and Robertsonian translocation-carrying rams. | |
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MedLine Citation:
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PMID: 1206629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A detailed analysis was made of the chromosomes in 1008 M II figures from three different types of heterozygous Robertsonian translocation-carrying rams (53,xy,t1; 53,xy,t3) and 225 M II figures from homozygous Robertsonian translocation-carrying rams (52,xy,t1t1; 52,xy,t3t3) and rams of normal karotype (54,xy). No hypermodal cells were recorded in either the normal or the homozygous rams, but from 4-5% to 9-2% of M II cells from the heterozygous rams were hypermodal. The heterozygous rams also produced a significantly higher level of hypomodal cells suggesting that, in addition to non-disjunction, lagging at anaphase I may have occurred. There were also distinct differences in M II aneuploid spermatocyte frequency between heterozygous versus normal and homozygous rams. Fewer balanced translocation X-carrying M II cells were recorded than expected in three of the four 53,xy,t2 rams. This coincides with mating data which suggest that 26,x,t2 gametes may occur less frequently than expected. Since ewes of normal karotype mated to 53,xy,t rams conceive to first service at a rate equal to or better than normal mating groups, and because no blastocysts with unbalanced karotypes associated with the t1 translocation have been recorded, it is suggested that only euploid spermatozoa are involved in fertilization. In the sheep, aneuploid spermatocytes probably degenerate before sperm maturation. |
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Authors:
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H M Chapman; A N Bruère |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 45 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1975 Nov |
Date Detail:
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Created Date: 1976-03-20 Completed Date: 1976-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 333-42 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy* Animals Chromosome Aberrations* Heterozygote Homozygote Male Meiosis Sheep / physiology* Spermatocytes / ultrastructure* Spermatozoa / ultrastructure* Translocation, Genetic* |
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