Document Detail

The on-freezing phenomenon: cognitive and behavioral aspects.
MedLine Citation:
PMID:  21785692     Owner:  NLM     Status:  In-Data-Review    
Freezing of gait is a warning sign of Parkinson's disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. These aspects have been even more evident, when compared with the results obtained by a group of PD patients, without freezing.
Rita Moretti; Paola Torre; Rodolfo M Antonello; Francesca Esposito; Giuseppe Bellini
Publication Detail:
Type:  Journal Article     Date:  2011-07-14
Journal Detail:
Title:  Parkinson's disease     Volume:  2011     ISSN:  2042-0080     ISO Abbreviation:  Parkinsons Dis     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101539877     Medline TA:  Parkinsons Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  746303     Citation Subset:  -    
Medicina Clinica, Ambulatorio Complicanze Internistiche Cerebrali, Dipartimento Universitario Clinici di Scienze Mediche Tecnologiche e Traslazionali, Università degli Studi di Trieste, Ospedale di Cattinara, Strada Fiume 447, 34149 Trieste, Italy.
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